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Thus, the human skin is primarily regulated by paired heterodimers composed of RAR-gamma and RXR-alpha.[18] These heterodimers go on to bind to a specific area in deoxyribonucleic acid (DNA) known as retinoic acid response elements (RARE)

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However, once the animal model is established, it is necessary to select indicators to judge and evaluate whether the plateau animal model is successful given that it is impossible to quantify the symptoms of animals based on human standards

doi: 10.2164/jandrol.111.013193 [DOI] [PubMed] [Google Scholar] 92