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doi: 10.1038/s41467-020-15457-9 79 NguyenTTKosciolekTDalyREVzquez-BaezaYSwaffordAKnightRet al

Within endosomes, zinc contributes to tethering and fusion by stabilizing zinc-dependent tethering factors, such as the zinc finger protein EEA1, which facilitates SNARE complex assembly and ensures efficient cargo sorting and receptor recycling 99,100

Furthermore, mitochondrial dysfunction, neuroinflammation, and oxidative stress are central to biochemical events in PD such as S aggregation, dysregulated sirtuin activity, and impaired insulin signaling (Picca et al., 2020)

Laengle J, Kabiljo J, Hunter L, Homola J, Prodinger S, Egger G, et al

The second group comprises non-glutathione disulfide substrates (RS 2 or RSSR) that are reduced by two molecules of GSH, yielding one dithiol product or two monothiol products (R(SH) 2 or RSH + RSH) and GSSG (Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Shih A.Y., Erb H., Sun X., Toda S., Kalivas P.W., Murphy T.H