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Symptoms may simply persist or gradually worsen, and some patients experience repeated flares that affect sleep, energy, concentration, and overall quality of life

Unlike whole-body Gclc KO mice, liver-specific Gclc L-KO mice did not have any difference in survival or body weight following Gclc deletion (Fig

Jung M., Mertens C., and Brune B., Macrophage Iron Homeostasis and Polarization in the Context of Cancer, Immunobiology 220 (2015): 295304

Because kinases generally phosphorylate a spectrum of substrate proteins, it is unlikely that ISR kinases only phosphorylate eIF2

Given the high mortality and limited therapeutic options, there is a pressing need for a comprehensive understanding of this disease

10.1093/ajcn/nqz041 79 WaniA
