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There appears to be a proportional relationship between VGLUT levels and glutamatergic synapse response

Scientists are increasingly

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The Journal of Biological Chemistry, 289 (35), 2469124699

Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig

They showed Mn overexposure reduced dopamine concentrations in the striatum, accompanied by impaired motor performance (Ivleva et al., 2022