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112 Indeed, the cardiomyocyte-specific deletion of EP3 induces eccentric cardiac hypertrophy and cardiac fibrosis in 1618-week-old mice, supposedly by inactivating the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway and affecting matrix metal proteinase 2 (MMP-2) expression

Fis is essential for Yersinia pseudotuberculosis virulence and protects against reactive oxygen species produced by phagocytic cells during infection

Additionally, understanding the interplay between glutamine metabolism and epigenetic regulation offers a novel perspective for leveraging glutamine supplementation as an adjunct therapy to conventional cancer treatments, potentially enhancing their efficacy and improving patient outcomes

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Glycine transporter type 1 inhibitors Glycine transporter inhibitors are a class of pharmacological agents that modulate glycine uptake through specific synaptic transporters in the central nervous system (Cioffi and Guzzo, 2016)