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we will look at where the gastric-emptying data are strong (mostly for pramlintide, not cagrilintide), where they are thin, and where a plausible mechanism may not translate into a durable clinical effect

4.1.3 GLP-1 receptor agonists Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), traditionally recognized for glycemic regulation and weight management, exhibit renoprotective effects in DKD through multifactorial mechanisms

Specifically, these analyses replicated prior results showing that daytime self-reported body temperature was associated with greater depressive symptoms 19,20 and build on one prior study showing that the asleepawake body temperature difference was more than twice as large among controls relative to individuals with depression 21

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However, epalrestat outperformed methylcobalamin in all of the pain-related modalities

Key cautions to keep in view Research status and evidence limits: Much of the mechanistic work is preclinical, and human data are limited