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Its deficiency is seen in people with poor nutrition, infection, cancer, surgery, alcohol, pernicious anemia, medications (PPIs or other acid-suppressing drugs), exposure to nitrous oxide (during surgery or recreational use), stomach/intestinal problems such as intestinal dysbiosis, leaky gut or gut inflammation, atrophic gastritis or hypochlorhydria (low stomach acid) and/or nerve damage
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A vitamin B12 deficiency can lead to pale skin and yellowing of the skin, called jaundice

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Combining both compounds in a single capsule allows researchers to study their complementary effects on the NAD+ pathway within a single protocol
