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4 as follows [60]: Serum oxidative stress Malondialdehyde (MDA) levels [70] (CAT

doi: 10.3389/fimmu.2019.03090 93 RoweDBLeWSmithRGAppelSH

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Clinical trial design for triglyceride-rich lipoprotein-lowering therapies: JACC focus seminar 3/3

If H 2 O 2 remains in the mitochondrial matrix it reacts with the ferrous (Fe 2+ ) iron via the Fenton reaction yielding the hydroxyl free radical which is highly reactive toward DNA and polyunsaturated fatty acids (PUFA)
