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The Keio University Animal Research Committee approved all animal procedures used in this study [12048-(3)]

ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways

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References White, A., Stremming, J., Wesolowski, S

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