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IFN activates the JAKs/STAT pathway, increasing the expression of CXCR3 and its ligands CXCL9, CXCL10, and CXCL11, responsible for CD8 + T cell recruitment and apoptosis in melanocytes

[DOI] [PubMed] [Google Scholar] 111.Tunon M.J., Miguel B.S., Crespo I., Jorquera F., Santamaria E., Alvarez M., Prieto J., Gonzalez-Gallego J

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Moreover, HCV modulates the activity of microsomal triglyceride transfer protein (MTP) and sterol-regulatory-element-binding-protein (SREBP) involved in the pathogenesis of liver steatosis and hypolipidemia 32

177 During T cell activation, the TCR complex aggregates with signaling molecules in lipid rafts, such as the Src family lymphocyte-specific protein tyrosine kinase (Lck), thereby increasing signal transduction (Fig