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It is also recognized as a superordinate, critical hub within the hierarchical structure of cytokine networks underlying various chronic inflammatory diseases (Figure 1)

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An 8-week on, 4-week off schedule provides predictable timing

The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

However, people with certain medical conditions or those receiving B12 injections may experience negative side effects or overdose symptoms

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