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The very first illustration in this blog shows that IGF-1 will increase oxidative stress

Tong H, Luo L, Wu C, Wang H, Cheng Y, Wu Z
doi: 10.1016/j.jid.2019.01.006

His performance topped his senior year off on a winning note, after he led Hill School to the Mid-Atlantic Prep League (MAPL) championship for the seventh-straight year, losing to Blair Academy, and the Pennsylvania Independent Schools Athletic Association (PAISAA) championship, where the Rams lost to Phelps School in the title game
doi: 10.1134/S1995082917010187

[56] Smith ZD, et al
