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Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B deficiency with metformin therapy and vitamin B supplements: the National Health and Nutrition Examination Survey, 19992006

2001 in Endocrinology showed reduced body weight gain with 14-day AOD-9604 in obese (ob/ob) mice and identified the beta-3 adrenergic receptor dependency

In pre-clinical research, inhibiting NNMT is studied for its effects on NAD+ salvage pathway activity and methyl-donor availability

Another factor to consider is individual biochemistry