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It functions as a multi-pathway signal peptide affecting fibroblast activity, copper trafficking, antioxidant signaling, and broad gene expression

However, their elevated concentration, affects the cell by causing cellular injury, eventually leading to PCD

The cellular Fe(II) is now part of what is called the cellular labile iron pool (LIP), which is radially accessible for utilization in a variety of cellular processes [74]

A 2015 meta-analysis of 54 case-control studies found that the MTHFR C677T polymorphism was associated with an increased risk of preeclampsia, especially in Caucasian and Asian populations (27)

The level of free oxygen radicals decreased in the supplemented group compared to the placebo group, an indicator of OS, and DNA damage was increased in the placebo group compared to supplemented group [23]