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Ferroptosis regulation via the NAD(P)H/FSP1/CoQ10 pathway is another Exos-mediated mechanism [17]

demonstrated that BDL-rats treated with edaravone, at a dose of 110 mg/kg/day intraperitoneally for 14 days, show significant improvements in cholestasis-associated hepatic and renal injury, via reduction of ROS levels, lipid peroxidation, protein carbonylation, and GSSG levels

The complementary nature of these mechanisms explains why the combination often produces results that exceed what either peptide achieves individually

Therefore, despite some encouraging outcomes, NSC transplantation has generally yielded inconsistent results across PD models, with limited evidence of sustained nerve regenerationlikely reflecting variability in cell sourcing, host immune responses, and the complex interplay between transplanted cells and the diseased microenvironment