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This is the dual-agonist component that tirzepatide shares with retatrutide

[DOI] [PubMed] [Google Scholar] Collins DC, Balikian HM, and Preedy JR (1976) Splanchnic and intestinal uptake and formation of estriol and estriol conjugates in the dog in vivo

If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

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