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Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

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For CME_d, D180 and R289 form stable hydrogen bonds with the N- and C-termini of CME, respectively, stabilizing the L1 and L4 regions around the metal site and resulting in relatively smaller RMSF values

Muscle tone is normal

10.1212/01.WNL.0000159743.08996.99 105 FragalaM

However, over-supplementation may cause headaches, anxiety, or sleep issues in sensitive individuals