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Indeed, upregulation of lactate, which may be present in the microenvironment as a consequence of increased glycolysis in cancer cells, has been shown to promote glutamine metabolism through a HIF2- and MYC-dependent mechanism, potentially providing a way for tumor to reprogramme itself towards increased glutaminolysis (8)

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Thoms S, Grnborg S, Grtner J

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

doi: 10.1016/0005-2760(96)00066-5 39 RanaMDashAKPonnusamyKTyagiRK