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44-]-TE 12/28/1944 Flt

Further investigations are needed to elucidate the specific mis-spliced genes and proteins directly influenced by SF3B1 mutations together with the crosstalk between SF3B1 and MAPK pathway in tumorigenesis of MM, and the findings may provide a new perspective for targeted therapy

doi: 10.1111/obr.13646 91

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By using publicly available RNA-seq and RNA immunoprecipitation (RIP)-seq data, we predict the role of HuR in GLS splicing and confirm its binding to its mature mRNA