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Abstract The bloodbrain barrier (BBB) is a critical structure that maintains the brains homeostasis by regulating the transport of molecules and protecting it from harmful substances

A deficiency of l-carnitine can lead to impaired mitochondrial function and cellular metabolic alterations that may underlie many disease states

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Four small molecules [sulfamethoxazole, ketoprofen, MES (4- morpholineethanesulfonic acid), glyphosate], and 4-(2-hydroxyethyl)-1- piperazineethanesulfonic acid (HEPES) were used for the spiking sample, and Acetyl-d3-L-carnitine hydrochloride used as the internal standard in selected reaction monitoring (SRM) analysis was purchased from Sigma-Aldrich (St

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