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We explicitly define the acute phase as 07 days post-stroke and the chronic phase as strictly beyond 1 month post-stroke

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The dual nature of reactive species is well known

[26] identified elevated plasma neurofilament light chain (NfL) levels in ME/CFS patients, which was correlated with cognitive deficit and autonomic dysfunction, thus implicating NfL as a promising biomarker for neuroaxonal damage and associated neurological dysfunction in ME/CFS

View Abstract Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis

Mice lacking TRPV4 channels are less sensitive to mechanical stress (131) whereas mice with ablated TREK/TRAAK channels are hypersensitive to mechanical forces and local pH changes (136)