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In some specific research protocols, alternatives are used: Sterile water for injection (WFI) , when the entire contents of the vial are used at once and a preservative is not needed Physiological saline (0.9% NaCl) , in some applications requiring an isotonic environment Acidic solvents (e.g

Acute pain begins suddenly for a short duration and is usually due to an injury, illness, or surgery

Animal studies show no toxicity even at doses 1,000 higher than typical use, but that doesn't mean high doses are risk-free in humans (Sikiric et al., 2014)

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Non-dietary vitamin B12 deficiency Discuss the need for intramuscular (IM) hydroxocobalamin with each person
