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This pathway is dysfunctional in cancer and other syndromes and is known to short circuit glycolytic intermediates towards formate in a manner similar to the Warburg pathway that diverts glycolytic intermediates to lactate instead of feeding the tricarboxylic acid (TCA) cycle 31

Conversely, five natural products have demonstrated inhibitory effects on autophagy in ovarian cells, a mechanism that may also offer protective benefits under certain pathological conditions

doi: 10.3390/ijms241914876

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Prognostic value of sarcopenia in adults with solid tumours: A meta-analysis and systematic review

Thus, a high iron content and a low antioxidant content make oligodendrocytes one of the most vulnerable cell classes to oxidative stress in the CNS