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They further demonstrated that SIRT1 and SIRT6 couple a switch from increased glycolysis to increased fatty acid oxidation as early inflammation transitions to late inflammation, which requires NAD + production using nicotinamide phosphoribose transferase (120)

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these elevations were diminished when OXY was co-administrated with LPS

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doi: 10.1016/j.clnu.2018.08.032