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Yes, but temperature management is critical

Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 , and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48
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Quantifying triglyceride-rich lipoprotein atherogenicity, associations with inflammation, and implications for risk assessment using non-HDL cholesterol

Hypothalamic hypocretin (orexin): robust innervation of the spinal cord

Most of that research used oral supplements, not injections
