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26,27 Here, we demonstrate that bacterial enzymes can similarly be used to manipulate compartment-specific GSH pools in cells and mouse models

NO helps blood vessels widen in several ways: It reduces calcium release from smooth muscle cells' sarcoplasmic reticulum It helps put calcium back into the sarcoplasmic reticulum The cGMP pathway reduces smooth muscle tension [1] These actions work together to widen blood vessels and improve l-arginine blood flow [11]

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However, hyperuricemia plays a role in promoting inflammation, oxidative stress, and endothelial dysfunction underscores its potential contribution to disease pathogenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Alexiou G.A., Lianos G.D., Ragos V., Galani V., Kyritsis A.P