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doi: 10.1016/s0074-7696(08)60529-x

Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G et al

Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues

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Results Fragment-based drug design and chemistry Utilizing actives identified in a quantitative high-throughput screen against Schistosoma mansoni TGR 20,35 , 92 commercially available low molecular weight (MW) compounds/fragments were tested by X-ray crystallography 33,34,36

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