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Xia et al., 2021)

7 9 Addressing OSD signs and symptoms early may help mitigate complications

Science 1998, 280 (5365), 915918

pair clinical trajectories (e.g., MDS-UPDRS) with biochemical readouts (Nrf2 transcriptional signature, MDA/4-HNE, iron/ferroptosis panels) to confirm on-target exposure

While the molecular ruthenium catalyst and the nanoreactors without carbon fluorinated moieties were cytotoxic in the low micromolar range in a 21% O 2 atmosphere, these compounds lost their therapeutic effect in a 1% O 2 atmosphere

Evidence of redox imbalance and mitochondrial dysfunction in Niemann-Pick type C 1 patients: The in vitro effect of combined therapy with antioxidants and -cyclodextrin nanoparticles