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Transcription factor Nrf2 has shown the ability, both in in vitro and in in vivo experiments, to activate a series of vitagenes including (Hsp) Hsp32, Hsp70, and thioredoxin, conferring protection against oxidative stress, and contributing to establish a cytoprotective state in inflammation and neurodegenerative disorders [135, 136]

2 Intracellular GSH production is dispensable for tumor growth in the mouse flank

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The day/night pattern of leptin is influenced by both the endogenous circadian pacemaker and behavioral factors such as sleep and food intake (285)