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Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function

Regan EA, Bowler RP, Crapo JD

Macromolecules 48 , 51205131

It has been hypothesized that the peptide might modulate cellular stress responses and promote the maintenance of cellular function during aging

(Created with biorender.com) Thus, it is questionable whether this mechanism can be applied to other cell types, particularly hepatocytes with their complex, multi-layered antioxidant systems
Promising results are emerging from clinical trials of CAR T cells targeting the B cell protein CD19 in patients with B cell-driven autoimmune diseases
