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However, systemic administration of naked adenoviruses may induce severe hepatotoxicity and trigger rapid immune responses in the host due to their highly immunogenic viral capsids, leading to severe inflammatory reactions [32, 40]

FDA-clearance or approval is required anytime something artificial is being inserted into the body or being used to treat a human being

This is consistent with the observation that capsid proteins obtained from BSO-treated cells can still associate with RNA to form 150S, albeit unable to produce mature virion

doi: 10.1186/s10020-025-01092-x 47 LiuZ

Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters

In some embodiments, the RIG-I pathway agonist is RGT100