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therefore, it is speculated that the degree of arterial calcification may be related to the high concentration of TMAO ( via promoting fatty acid metabolism and mitochondrial dysfunction ( Taken together, previous studies show that TMAO can aggravate the process of atherosclerotic plaques by promoting vascular calcification

Fuchs CD, Trauner M

These esterified fatty acids have a limited capacity for penetration to the mitochondrion, requiring a physiological carrier

Adverse events collected were: angina (change in frequency), stroke, transient ischemic attack, MI, congestive heart failure, cardiac revascularization, cerebral revascularization, peripheral revascularization, high blood pressure and diabetes (new diagnosis only)

Trimethylamine/Trimethylamine-N-Oxide as a key between diet and cardiovascular diseases

doi: 10.1093/jbcr/iraa176