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After positive results from the Veterans Affairs HDL-C Intervention trial (VA-HIT) trial, showing a 22% reduction in ASCVD with gemfibrozil (1,200 mg/day) in the 1990s [8], major fibrate trials, including the Lower Extremity Arterial Disease Event Reduction (LEADER) [5], Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) [6], and Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid [7] in the 2000s, failed to demonstrate ASCVD prevention with fibrates

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Antibody neutralization experiments Melanocytes were preincubated with one of the following antibodies at a final concentration of 10 g/mL for 30 min: rabbit IgG control (#ab172730, Abcam, Cambridge, UK), mouse IgG control (#ab37355, Abcam), anti-dystroglycan (#ab234587, Abcam), anti-integrin 1 (#PA5-29606, Thermo Fisher Scientific), and anti-integrin 7 (#ab195959, Abcam)

doi: 10.1002/oby.22025

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