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These findings do not establish a direct cause-and-effect relationship, but they suggest that long-term high-dose supplementation may not be necessary for individuals with adequate B12 status

doi: 10.1016/j.jacc.2013.11.004

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(12) Watch out for these signs and symptoms of a B12 deficiency: Fatigue Muscle weakness or muscle spasms Anxiety or depression Brain fog Unexplained weight loss Frequent colds Pins and needles Cognitive impairment Low blood pressure Incontinence

According to the NHS, addressing these types of nerve problems often requires a more rigorous approach

The mechanism of the hyperglycaemic action of synthetic peptides related to the C-terminal sequence of human growth hormone