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Prx1 Cys83 binds to cullin-3, a ubiquitin ligase modulating Nrf2 ubiquitination [150] , and thereby inhibits degradation of Nrf2 allowing transcription of anti-ferroptotic enzymes [149]

10.1016/j.jpba.2013.03.008 158 YangC

Abbreviations: Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma-2 CCK8 cell counting kit-8 CDK1 cyclin-dependent kinase 1 cyclin D1 cell cycle protein D1 EMT epithelial-mesenchymal transition GEM gemcitabine GM gut microbiota HCC hepatocellular carcinoma HGF hepatocyte growth factor IL-6 interleukin-6 JAK2/STAT3 Janus kinase 2/signal transducer and activator of transcription 3 LF lactoferrin MAPK mitogen-activated protein kinase mTOR mammalian target of the rapamycin NCs nanocapsules NF-B nuclear factor kappa B NO nitric oxide Nosip nitric oxide synthase-interacting protein PD-1 programmed cell death protein 1 PI3K/Akt phosphoinositide 3-kinases/protein kinase B ROS reactive oxygen species Se selenium SFB sorafenib SIRT sirtuins TCM Traditional Chinese Medicine TGF- transforming growth factor- TME tumor microenvironment TNF- tumor necrosis factor-alpha YY1 Yin Yang 1 References [1] Sung H, Ferlay J, Siegel RL, et al

Med Genet 47 , 429432 (2010)

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