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I can always tell when a doctor has no idea what they are doing when they recommend that a patient stop taking vitamin B12 because their blood level is high

Prooxidant activity of curcumin copper-dependent formation of 8-hydroxy-2-deoxyguanosine in DNA and induction of apoptotic cell death

doi: 10.1007/s13668-023-00472-1 66 KontaniN.OmaeR.KagebayashiT.KanekoK.YamadaY.MizushigeT.et al

Not in animal models

FIGURE 1 The first example in Figure 2 shows that 7-chloro-4-hydroxyquinoline ( FIGURE 2 The second example in Figure 2 shows that chloroquines side chain is a piperazine ring skeleton ( The third example in Figure 2 shows that the hydroxychloroquine side chain is coiled around the quinoline ring as piperazine as well as the oxazine ring substituted at 4-position of the parent quinoline ring structure

As the implanted tumour cells lack p53 expression (ID8 Trp53 / ), and p21 is a p53-dependent gene, we wanted to confirm that (a subset of) the p21-positive cells were tumour derived