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Description
Rebouche CJ, Engel AG
The efficacy and safety of mipomersen have been studied in randomized clinical trials evaluating patients with homozygous familial hypercholesterolemia, heterozygous familial hypercholesterolemia, or severe hypercholesterolemia 113,114,115
Reduced NO levels lead to increased vascular stiffness and impaired blood flow (Maiuolo et al
Further research is needed to elucidate these compensatory mechanisms
Some of the side-effects may be rare but serious
The relationship of multiple ACs in vivo and psychiatric disorders such as depression has yet to be further investigated
