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Methods: Adult male Sprague-Dawley rats were exposed, whole body, 5 days/week for 4 weeks to HnB mainstream

Due to the perinatal lethality of Gdf11-knockout mice [39,40] , which exhibit homeotic skeletal transformations, cleft palate, and renal agenesis, the functions of GDF11 in postnatal tissues are less explored

This study also determined the role of GSH in PfK13-mediated resistance and revealed 1) that modulation of PfK13 levels or localisation modifies GSH levels, and (2) that elevated GSH decreases artemisinin potency using in vitro ring-stage survival assays

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