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2 Another common SNP in the MTHFR gene, known as A1298C, involves the replacement of an adenine (A) with a cytosine (C)

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doi: 10.1016/j.tibs.2015.12.001 10 ChungSDzejaPPFaustinoRSPerez-TerzicCBehfarATerzicA

3.3.2 Alkaloids From the deep-sea fungus Trichoderma MCCC 3A01244, 25 compounds were isolated, among which Trichocarboline A, a -carboline alkaloid, exhibited significant biological activity

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Nevertheless, drawbacks of EDEA and BDEA, such as high hydrophobicity and low solubility, as well as the strong binding to serum albumin, need to be solved in future structural optimization to obtain better membrane permeability and solubility [204]