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In addition to its demonstrated efficacy in the treatment of sepsis, aPC is currently being investigated for the treatment of numerous conditions

The anterior inferior periocular soft tissue and orbital fat pad expand in volume with aging [8,10], leading to a sunken in appearance to the eyes and pronouncing lid laxity

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Chronic renal failure and uremia represent states wherein high blood levels of Hcy are seen [70], and with decline in function these patients become more and more hyperhomocysteinemic [93]

Dystrophin: the protein product of the duchenne muscular dystrophy locus