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Phase I trial of the PKC activator/downregulator bryostatin 1 (NSC 339555) and high-dose Ara-C (HIDAC) in patients with refractory acute leukemia

Therefore, inhibition of EP300 has promising potential to inhibit myeloid mimicry in RMC tumor cells

Vicente-Gutierrez C, Bonora N, Bobo-Jimenez V, Jimenez-Blasco D, Lopez-Fabuel I, Fernandez E, Josephine C, Bonvento G et al (2019) Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

With only one normal -globin gene, the synthesis of chains is markedly reduced, and tetramers of -globin, called HbH, form

PMID 14715910
