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The covalent coupling of A-GSH targeting molecules, dopamine or ibuprofen drugs to the 3-PLG backbone by EDC/NHS reaction resulted in nanocarriers with hydrodynamic diameter in the 300500 nm range (Fig

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Notably, fasting triggers heightened O-GlcNAc levels within the ventromedial hypothalamus (VMH), while specific Ogt knockout within VMH neurons precipitates rapid weight gain, adiposity, and reduced basal energy expenditure in normally nourished mice [89]

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While this finding is of great interest to the field of konzo as well as other neurodegenerative diseases, we cannot determine if the reduction in GPx3 is a result of disease or an inherent contributing factor for disease that is triggered by a micronutrient deficiency or underlying genetic variability