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The loss of SNpc dopaminergic (DA) neurons causes bradykinesia and stiffness, the two primary motor symptoms of PD

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This epithelial damage and subsequent unrestricted paracellular permeability has been observed in graft vs host disease and gastrointestinal conditions such as Crohn's disease and ulcerative colitis [39], and may play a role after acute cardiovascular events, such as after a stroke, where damage to intestinal epithelial cells is severe [40]

Similar cellular migration patterns from niches in intervertebral disc and in knee-joint regions detected by in situ labeling: an experimental study in the New Zealand white rabbit