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DOX acts by inhibiting topoisomerase II 7,11
Additionally, the untransformed breast epithelial cells upregulate PDK4 to inhibit PDH and attenuate the flux of glycolytic carbon into mitochondrial oxidation, consequently suppressing anoikis (the absence of the home environment) upon detachment from ECM (261)
Suchting, R
ISBN 978-0-12-385853-5
The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury
FOLR-targeted small-molecule conjugates have also shown promising results in early-stage clinical trials with microtubule destabilizing agents
