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Could lifetime lead exposure play a role in limbic-predominant age-related TDP-43 encephalopathy (LATE)

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In personal communications, the researcher noted that, To our knowledge, GSH is an active substance and metabolized mostly in the small intestine

ZnT1 and ZnT4 were present in the entire senile plaque, ZnT3, ZnT5, and ZnT6, were present in the periphery of the plaque, and ZnT7 was expressed in the center of the senile plaque [194]

Theoretical concerns similar to all GH-elevating interventions include potential effects on glucose metabolism, possible interactions with insulin signaling, and unknown long-term effects on cellular proliferation

Schwabe RF, Brenner DA