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A prognostic model was built with Cox and Least Absolute Shrinkage and Selection Operator (LASSO) methods and validated by Kaplan-Meier analysis, Receiver Operating Characteristic (ROC) curves, and Principal Component Analysis (PCA)

DSM-IV = Diagnostic and Statistical Manual of Mental Disorders (4th ed

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Melatonin may also play a part in chelating transition metals involved in the highly damaging Fenton and Haber-Weiss reactions, helping buffer formation of toxic hydroxyl radicals