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They are capable of sensing a variety of pathogens, cellular damage signals, or metabolic abnormalities, which trigger the activation of downstream caspase-1

Authorship note: YB, LW, and CA contributed equally to this work

This mitochondrial metabolon prevents unwanted crosstalk of the substrate cholesterol with other pathways, optimizing substrate concentration and targeting to CYP11A1

HRT (hormone replacement therapy) is a broad term that refers to replacing or optimizing any deficient hormones, including thyroid, growth hormone, estrogen, progesterone, or testosterone

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