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This activation can change neuronal excitability and synchronization by modulating the function and expression of receptors, ultimately contributing to the development of epilepsy [5]

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This results in energetically inefficient anaerobic glycolysis and defective tricarboxylic acid cycle, with sustained urinary excretion of pyruvate, orotate, citrate, -ketoglutarate, nitrogen-rich compounds and amino acids

Garbutt and Little 2014