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Thus the shift of macrophage/microglia from activation to deactivation and vice-versa depends on the tissue infected by HIV-1 and on the local microenvironment

this effect involved inhibition of key proteins that regulate membrane-vesicle fusion, such as N-ethylmaleimide-sensitive fusion protein (NSF) and synaptosomal-associated protein of 25 kDa (SNAP-25)

Manavi MA, Fathian Nasab MH, Mohammad Jafari R, Dehpour AR (2024) Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents