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Acknowledgements We thank J.E

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The most common causes of dementia include: Alzheimer's disease Vascular dementia Parkinson's disease Dementia with Lewy bodies Frontotemporal dementia Severe head injury Other less common causes include: Huntington's disease Leukoencephalopathies, diseases that affect the deeper, white-matter brain tissue Creutzfeldt-Jakob disease, a rare and fatal condition that destroys brain tissue Some cases of multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) Multiple-system atrophy, a group of degenerative brain diseases that affect speech, movement, and autonomic function Infections such as late-stage syphilis Although all types of dementia are progressive, the term progressive dementia refers to dementias that happen rapidly, over the course of weeks or months

The only FDA approved therapy for RP is Luxturna (Spark Therapeutics), a subretinal gene therapy to correct RPE65 -induced retinal degeneration

Br J Pharmacol 118(6):14611468 Yamagata K, Hakata K, Maeda A, Mochizuki C, Matsufuji H, Chino M, Yamori Y (2007) Adenosine induces expression of glial cell line-derived neurotrophic factor (GDNF) in primary rat astrocytes